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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 111, No. 9, 2016, pp. 594-596
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Bioline Code: oc16092
Full paper language: English
Document type: Special Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 9, 2016, pp. 594-596
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Genome-wide analyses of HTLV-1aD strains from Cape Verde, Africa
Zanella, Louise; Pina-Araujo I, Isabel de; Morgado, Mariza G & Vicente, Ana Carolina Vicente
Abstract
We characterised and reported the first full-length genomes of Human T-cell Lymphotropic Virus Type 1 subgroup
HTLV-1aD (CV21 and CV79). This subgroup is one of the major determinants of HTLV-1 infections in North
and West Africa, and recombinant strains involving this subgroup have been recently demonstrated. The CV21 and
CV79 strains from Cape Verde/Africa were characterised as pure HTLV-1aD genomes, comparative analyses including
HTLV-1 subtypes and subgroups revealed HTLV-1aD signatures in the envelope, pol, and pX regions. These genomes
provide original information that will contribute to further studies on HTLV-1a epidemiology and evolution.
Keywords
HTLV-1; HTLV-1aD complete genome; HTLV-1aD signatures; Cape Verde; Africa; GC Content
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