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Emergence of Acinetobacter baumannii  ST730 carrying the blaOXA-72 gene in Brazil
Pagano, Mariana; Rozales, Franciéli P; Bertolini, Diego; Rocha, Lisiane; Sampaio, Jorge LM; Barth, Afonso L & Martins, Andreza F
Abstract
Over the last decade, Acinetobacter baumannii resistant
to carbapenems has emerged in many medical
centres and has been commonly associated with high
morbimortality. In Brazil, this resistance is mainly attributed
to the spread of OXA-23-producing clones and,
to a lesser extent, to OXA-143-producing clones. Here,
we describe, for the first time, two OXA-72-producing A.
baumannii isolates in southern Brazil to a broad spectrum
of antibiotics, except polymyxin B and tigecycline.
Molecular typing by multilocus sequence typing (MLST)
demonstrated that both OXA-72-producing isolates belong
to a new sequence type (ST), ST730, which was
recently identified in OXA-23-producing A. baumannii
isolates in São Paulo, Brazil. We demonstrate that the
two A. baumannii ST730 isolates carrying blaOXA-72 share
a common ancestral origin with the blaOXA-23 producers
in Brazil. This observation reinforces the importance of
strain-typing methods in order to clarify the dynamics
of the emergence of new clones in a geographic region.
Keywords
Acinetobacter baumannii; MLST; OXA-72
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