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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 4, 2017, pp. 237-246
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Bioline Code: oc17031
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 4, 2017, pp. 237-246
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Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions: a population-based study, 2001-2013
Moraes, Camile de; Moraes, José Cássio de; Silva, Gabriela Drummond Marques da & Duarte, Elisabeth Carmen
Abstract
BACKGROUND Meningococcal C conjugate (MenC) vaccine was introduced as part of the Brazilian National Immunisation Program in 2010 for children < 1 year of age.
OBJECTIVES The study objective was to evaluate the impact of this vaccination strategy.
METHODS An observational, mixed ecolobical and analytical study was conducted, based on time series panel data from surveillance records (2001-2013).
FINDINGS A total of 37,538 of meningococcal disease cases were recorded during the study period. Of these, 19,997 were attributed to serogroup C. A decrease in meningococcal disease serogroup C (MDC) incidence among children aged 1 year 65.2%; 95% confidence interval (CI): 20.5-84.7% and 1-4 years (46.9%; 95%CI: 14.6-79.1%) were found in the three years following vaccination introduction. Vaccination impact on the reduction of MDC incidence varied from 83.7% (95%CI: 51.1-100.0%) in the Midwest region to 56.7% (95%CI: 37.4-76.0%) in the Northeast region.
MAIN CONCLUSIONS Vaccination against MDC in Brazil had a positive impact on the population of children aged 1 year, across all regions, and on the 1-4 year-old cohort. Nevertheless, in our view there is scope for iproving the vaccination strategy adopted in Brazil.
Keywords
meningococcal disease; Neisseria meningitides; serogroup C conjugate vaccine; surveillance; vaccination impact
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