Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 112, No. 5, 2017, pp. 370-375
Bioline Code: oc17047
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 5, 2017, pp. 370-375
© Copyright 2017 - Memórias do Instituto Oswaldo Cruz
Antifungal activity of caspofungin in experimental infective endocarditis caused by Candida albicans |
Victorio, Gerardo Becerra; Bourdon, Lorena Michele Brennan; Benavides, Leonel García; Huerta-Olvera, Selene G; Plascencia, Arturo; Villanueva, José; Martinez-Lopez, Erika & Hernández-Cañaveral, Iván Isidro
BACKGROUND Infective endocarditis is a disease characterised by heart valve lesions, which exhibit extracellular matrix proteins
that act as a physical barrier to prevent the passage of antimicrobial agents. The genus Candida has acquired clinical importance
given that it is increasingly being isolated from cases of nosocomial infections.
OBJECTIVE To evaluate the activity of caspofungin compared to that of liposomal amphotericin B against Candida albicans in
experimental infective endocarditis.
METHODS Wistar rats underwent surgical intervention and infection with strains of C. albicans to develop infective endocarditis.
Three groups were formed: the first group was treated with caspofungin, the second with liposomal amphotericin B, and the third
received a placebo. In vitro sensitivity was first determined to further evaluate the effect of these treatments on a rat experimental
model of endocarditis by semiquantitative culture of fibrinous vegetations and histological analysis.
FINDINGS Our semiquantitative culture of growing vegetation showed massive C. albicans colonisation in rats without treatment,
whereas rats treated with caspofungin showed significantly reduced colonisation, which was similar to the results obtained with
liposomal amphotericin B.
CONCLUSIONS The antifungal activity of caspofungin is similar to that of liposomal amphotericin B in an experimental model
of infective endocarditis caused by C. albicans.
endocarditis; caspofungin; Candida albicans; liposomal amphotericin B
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