|
Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 7, 2017, pp. 469-473
|
Bioline Code: oc17062
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 7, 2017, pp. 469-473
en |
Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis
Gonçalves-Macedo, Liana; Lopes, Edmundo Pessoa; Domingues, Ana Lucia Coutinho; Markman-Filho, Brivaldo; Mota, Vitor Gomes & Luna, Carlos Feitosa
Abstract
BACKGROUND Hepatopulmonary syndrome (HPS) is defined as an oxygenation defect induced by intrapulmonary vasodilation
in patients with liver disease or portal hypertension. It is investigated in patients with liver cirrhosis and less frequently in those
with portal hypertension without liver cirrhosis, as may occur in hepatosplenic schistosomiasis (HSS).
OBJECTIVES To investigate the prevalence of HPS in patients with HSS, and to determine whether the occurrence of HPS is
influenced by concomitant cirrhosis.
METHODS We evaluated patients with HSS with or without concomitant liver cirrhosis. All patients underwent laboratory
testing, ultrasound, endoscopy, contrast echocardiography, and arterial blood gas analysis.
FINDINGS Of the 121 patients with HSS, 64 were also diagnosed with liver cirrhosis. HPS was diagnosed in 42 patients (35%)
and was more frequent among patients with concomitant liver cirrhosis than in those without cirrhosis (42% vs. 26%), but the
difference was not significant (p = 0.069). HPS was more common in those with spider naevi, Child-Pugh classes B or C and high
model for end stage liver disease (MELD) scores (p < 0.05 each).
MAIN CONCLUSIONS The prevalence of HPS was 35% in this study. The occurrence of liver cirrhosis concomitantly with HSS
may have influenced the frequency of patients presenting with HPS.
Keywords
neglected diseases; portal hypertension; oesophageal and gastric varices; ultrasound; schistosomiasis; hepatopulmonary syndrome
|
|
© Copyright 2017 - Memórias do Instituto Oswaldo Cruz Alternative site location: http://memorias.ioc.fiocruz.br
|
|