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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 7, 2017, pp. 520-522
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Bioline Code: oc17071
Full paper language: English
Document type: Letter to the Editor
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 7, 2017, pp. 520-522
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Molecular detection of mixed infections with multiple dengue virus serotypes in suspected dengue samples in Tamaulipas, Mexico
Requena-Castro, Rocío; Reyes-López, Miguel Ángel; Rodríguez-Reyna, Rosa Eminé; Palma-Nicolás, Prisco & Bocanegra-García, Virgilio
Abstract
This study aimed to detect dengue virus (DENV) serotypes
in serum samples obtained in Matamoros Tamaulipas,
Mexico, and to determine the concordance of
conventional nested reverse transcriptase polymerase
chain reaction (RT-PCR) and a serological test [enzymelinked
immunosorbent assay (ELISA NS1)]. Here, we
detected mixed infections consisting of four serotypes
of DENV. The most prevalent serotype was DENV-1,
followed by DENV-4. This is the first report of DENV-
4 in our region. Mixed infections were also detected in
21.5% of samples, and the predominant coinfection consisted
of DENV-1 and DENV-2. Therefore, continuous
epidemiological surveillance of DENV in this area is
required to predict future forms of dengue heterologous
infections and the effect of this on health care.
Keywords
serotypes; dengue; Flavivirus
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