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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 8, 2017, pp. 544-550
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Bioline Code: oc17075
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 8, 2017, pp. 544-550
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Risk factors for hepatitis B transmission in South Brazil
Pereira, Vagner Reinaldo Zingalli Bueno; Wolf, Jonas Michel; Luz, Camila Albani da Silva; Stumm, Gláucia Zuleide; Boeira, Thais da Rocha; Galvan, Josiane; Simon, Daniel & Lunge, Vagner Ricardo
Abstract
BACKGROUND Hepatitis B virus (HBV) infection is a major public health problem in Brazil. Several risk factors are involved in HBV
infection and their identification by a rational and essential approach is required to prevent the transmission of this infection in Brazil.
OBJECTIVES To evaluate risk factors associated with HBV infection in South Brazil.
METHODS A total of 260 patients with HBV and 260 controls from Caxias do Sul (state of Rio Grande do Sul, Brazil) participated
in this study. All participants were given a standard questionnaire to yield the sociodemographic information and to identify
HBV risk factors. HBV infection was detected by HBsAg test in all participants.
FINDINGS HBV infection in these cases was strongly associated with history of a family member HBV-infected, mainly mother
[odds ratio (OR) = 4.86; 95% confidence intervals (CI): 1.69–13.91], father (OR = 5.28; 95% CI: 1.58–17.71), and/or siblings (OR
= 22.16; 95% CI: 9.39–52.25); sharing personal objects (OR = 1.40; 95% CI: 1.37–2.38); and having history of blood transfusion
(OR = 2.05; 95% CI: 1.10–2.84).
CONCLUSIONS HBV infection was strongly associated with having a family member infected with hepatitis B, sharing personal
objects, and having history of blood transfusion.
Keywords
chronic hepatitis B; South Brazil; epidemiologic factors
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