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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 112, No. 8, 2017, pp. 572-576
Bioline Code: oc17079
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 8, 2017, pp. 572-576

 en Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
Damasceno, Jeziel D; Silva, Gabriel LA; Tschudi, Christian & Tosi, Luiz RO

Abstract

The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania check for this species in other resources spp. and Trypanosoma brucei check for this species in other resources and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.

Keywords
TERRA; Trypanosoma brucei telomere; Leishmania telomere; telomere transcription

 
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