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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 8, 2017, pp. 580-582
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Bioline Code: oc17081
Full paper language: English
Document type: Report
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 8, 2017, pp. 580-582
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Complete coding sequence of dengue virus serotype 4 isolated from field-caught mosquitoes in Thailand
Sittivicharpinyo, Thikhumporn; Wonnapinij, Passorn & Surat, Wunrada
Abstract
This report is the first to characterise the complete coding sequence of a dengue virus serotype 4 (DENV-4) genotype
I that was isolated from field-caught mosquitoes from an endemic area in Thailand in June 2013. The sequence
was assembled from high-throughput sequencing reads generated by Illumina HiSeq. Three out of four observed
intra-sample variants caused an amino acid variation in C, NS2B, and NS5 genes. The C4279T variant located in the
NS2B gene can indirectly affect the proteolytic activity of the NS3 protein. The sequence provided in this study might
be useful for the epidemiological study of DENV-4.
Keywords
DENV-4; next generation sequencing; amino acid variation; field-caught mosquitoes and Thailand
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