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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 10, 2017, pp. 719-722
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Bioline Code: oc17101
Full paper language: English
Document type: Short Communication
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 10, 2017, pp. 719-722
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Emergence of Trichosporon mycotoxinivorans (Apiotrichum mycotoxinivorans) invasive infections in Latin America
Almeida Jr, João Nobrega de; Francisco, Elaine Cristina; Barberino, Maria Goreth M de Andrade; Silva Filho, Luiz Vicente Ribeiro F da; Brandão, Oriana M; Colombo, Arnaldo Lopes & Padovan, Ana Carolina Barbosa
Abstract
We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. We also conducted
a literature review and a microbiological investigation, including that of clinical and environmental isolates. A
30-year-old man with chronic renal failure had disseminated infection after dialysis and a 15-year-old boy with cystic
fibrosis (CF) had pulmonary exacerbations with positive respiratory samples. A review of the relevant literature
revealed that deep-seated infections were related to immunosuppression or invasive devices, while most of the CF
patients showed a decline in lung function after positive cultures. Phylogenetic analyses revealed three distinct circulating
genotypes. MALDI-TOF mass spectrometry analysis showed similar spectral profiles and correctly identified
all strains/isolates. Biofilm production was documented in a bloodstream isolate and biofilm-producing cells showed
high minimum inhibitory concentrations against antifungals.
Keywords
Trichosporon mycotoxinivorans; Apiotrichum mycotoxinivorans; infection; biofilm; antifungal susceptibility; literature review
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