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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 10, 2017, pp. 728-731
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Bioline Code: oc17103
Full paper language: English
Document type: Special Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 10, 2017, pp. 728-731
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Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
Oliveira, Gisele R de; Siqueira, Juliana D; Finger-Jardim, Fabiana; Vieira, Valdimara C; Silva, Ronald L; Gonçalves, Carla V; Soares, Esmeralda A; Martinez, Ana Maria Barral de & Soares, Marcelo A
Abstract
The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant
in understanding biological differences in association with this disease. In this work, we have characterised
complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised
as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV
types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into
lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and
low oncogenic risk in asymptomatic women from southern Brazil.
Keywords
human papillomavirus; lineage; complete genome; southern Brazil
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