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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 112, No. 11, 2017, pp. 793-795
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Bioline Code: oc17114
Full paper language: English
Document type: Letter to the Editor
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 112, No. 11, 2017, pp. 793-795
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Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
Delatorre, Edson; Mir, Daiana & Bello, Gonzalo
Abstract
A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine
amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this
mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age
and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV
strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for
some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas.
Keywords
Zika Virus; NS1; infectivity; evolution
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