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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 89, No. 1, 1994, pp. 21-24
Bioline Code: oc94004
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 89, No. 1, 1994, pp. 21-24

 en Ultrastructural Aspects of Virus Replication in One Fatal Case and Several Other Isolates from a Dengue Type 2 Outbreak in Rio de Janeiro
Ortrud Monika Barth; Luzia Monteiro De Castro Crtes; Elisabeth Lampe & Jos Da Costa Farias Filho

Abstract

Dengue virus replication in mosquito cell cultures was observed by 
 electron microscopy in one fatal and 40 classical isolates from a dengue 
 type 2 outbreak in Rio de Janeiro and compared with the prototype New Guinea 
 C strain. All the Brazilian isolates presented, beside the classical 
 structured dengue virus particles, fuzzy coated virus-like particles, never 
 observed in the referencial New Guinea C virus strain. More numerous DEN-2 
 virus particles, fuzzy coated virus-like particles, defective virus particles 
 and smooth membrane structures inside the rough endoplasmic reticulum 
 characterized the unique fatal isolate examined.

Keywords
Flaviviridae dengue-2 virus replication ultrastructure

 
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