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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 89, No. 2, 1994, pp. 179-182
Bioline Code: oc94037
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 89, No. 2, 1994, pp. 179-182

 en Cytokine Responses to Dengue Infection among Puerto Rican Patients
Goro Kuno; Raymond & Bailey

Abstract

Recently, a strong correlation between high concentration of
tumor necrosis factor (TNFa) in blood and severity of dengue
hemorrhagic fever/dengue shock syndrome has been reported from
Asia and the Pacific. We wished to determine if a similar
relationship could be found in dengue patients in the Americas
where adult patients with severe syndromes have been observed
more frequently than in Asia where severe cases have been
observed mostly among children. 

The concentrations of interleukin-1 (IL-1beta) in hospistalized adult groups were significantly lower than that in outpatient adults. In contrast, the levels of interleukin 6 (IL-6) were significantly higher in hospitalized adults and children than in the corresponding outpatients. Levels of TNFa were higher in hospistalized children than in outpatient children or hospistalized adults. There was no significant difference in the levels of these three cytokines among hospitalized patients with or without hemorrhagic manifestations. Thus, an elevated IL-6 level was positively associated with severity of dengue infection in both children and adults, but IL-1beta level was negatively associated with severity in adults.

Keywords
dengue - cytokine - interleukin-1- interleukin-6 - tumor necrosis factor

 
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