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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 2, 1995, pp. 185-189
Bioline Code: oc95038
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 2, 1995, pp. 185-189

 en Schistosoma mansoni check for this species in other resources : Control of Female Fertility by the Male
Werner Kunz; Lutz Gohr; Christoph Grevelding; Peter Schubler; Gabriele Sommer; Marion Menrath & Anja Michel

Abstract

We have established an in vitro culture system for adult
schistosomes that allows monitoring gene expression for up to
more than ten days. Comparing female worms that are paired
with those that have been separated, we find distinct
differences, clearly documenting an influence of the male in
female gene expression. In perfect coincidence with classical
observations that were based on histological techniques, we
find that the male particularly regulates gene expression in
those tissues that are characterized by cell proliferation,
e.g. the vitellaria. From these results, we hypothesize that
the key target for the inductive signal that is transferred
from the male to the female during pairing is the activation
of a growth factor that stimulates mitotic proliferation.

Keywords
Schistosoma mansoni - in vitro culture - gene expression - male - female interaction

 
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