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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 3, 1995, pp. 401-405
Bioline Code: oc95078
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 3, 1995, pp. 401-405

 en Repair of schistosomal intestinal vascular lesions after curative treatment
Luciana Silva & Zilton A Andrade

Abstract

The process of repairing intestinal vascular lesions
induced by schistosomiasis in mice was studied before and
after curative chemotherapy, by means of histopathology
coupled with injections of the mesenteric veins with India
ink or plastic, in this case followed by corrosion in
strong acid.

The granulomas were avascular, mainly formed while within blood vessels, and were associated with distortion of the intestinal vasculature in their proximity, represented by tortuosities, focal dilatation, narrowing, and anastomosis of the mucosal and submucosal veins. Two to four months after cure of schistosontiasis involuting granulomas were seen to be slowly vascularized, a process going from the periphery toward the center of the granulomas. No intravascular granulomas were seen four months after treatment. The previously distorted mucosal and submucosal veins gradually regained their normal appearance, only a slight tortuosity remaining.

Keywords
Schistosoma mansoni - vascular lesions - repair - intestinal schistosomiasis

 
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