The compound Ro-15.5458/000, derivative in the class of
9-acridanone-hydrazones, was found to be effective against
Schistosoma mansoni in mice, killing almost all the skin
schistosomules (24 hr after infection), when administered
at the dose of 100mg/kg. In experintents carried out with
Cebus monkeys, the drug was shown to be fully effective at
25mg/kg, 7 days after infection. These data, associated
with the good results obtained earlier at the post-postural
phase of schistosomiasis, allow the inference that this
promising compound may be important in the set of
antischistosomal drugs, depending on further toxicological
and clinical tests.
