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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 3, 1995, pp. 425-428
Bioline Code: oc95083
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 3, 1995, pp. 425-428

 en Activity of 9-acridanone-hydrazone drugs detected at the pre-postural phase, in the experimental Schistosomiasis mansoni
Leogenes Horacio Pereira; Paulo Marcos Zech Coelho; Jose Oswaldo Costa & Romulo Teixeira De

Abstract

The compound Ro-15.5458/000, derivative in the class of
9-acridanone-hydrazones, was found to be effective against
Schistosoma mansoni in mice, killing almost all the skin
schistosomules (24 hr after infection), when administered
at the dose of 100mg/kg. In experintents carried out with
Cebus monkeys, the drug was shown to be fully effective at
25mg/kg, 7 days after infection. These data, associated
with the good results obtained earlier at the post-postural
phase of schistosomiasis, allow the inference that this
promising compound may be important in the set of
antischistosomal drugs, depending on further toxicological
and clinical tests.

Keywords
acndanone-hydrazones - Schistosoma mansoni - experimental schistosomiasis

 
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