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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 4, 1995, pp. 497-502
Bioline Code: oc95097
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 4, 1995, pp. 497-502

 en Antibody isotypes, including IgG subclasses, in ecuadorian patients with pulmonary paragonimiasis
Angel Guevara E; Juan Carlos Vieira G; Edmundo Araujo N; Manuel Calvopina H; Ronald H Guderian+ & Yves Carlier

Abstract

An ELISA test was developed to detect Paragonimus-specific
antibodies, including IgG subclasses, using P. mexicanus crude
water-soluble antigens. The test was standardized to detect
antibodies in sera of Ecuadorian patients with pulmonary
paragonimiasis and negative  controls from the endemic area.
The detected mean levels of IgG (0.753, SEM: 0.074) and IgM
(0.303, SEM: 0.033) were significantly elevated (P<0.05).
Within the IgG subclasses, IgG4 showed the highest detected
mean level (0.365, SEM: 0.116) and the other three subclasses
showed considerably lower mean levels (IgG1, 0.186  SEM: 0.06;
IgG2, 0.046 SEM: 0.01; IgG3, 0.123  SEM: 0.047). The number of
P. mexicanus eggs found in sputum of infected individuals
showed a positive correlation with the level of antibodies
detected for IgM, IgG and its subclasses (P } 0.001). The
relevance of these findings in Ecuadorian patients suffering
from pulmonary paragonimiasis is discussed.

Keywords
Ecuador - pulmonary paragonimiasis - IgM - IgG - IgG subclasses

 
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