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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 4, 1995, pp. 503-506
Bioline Code: oc95098
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 4, 1995, pp. 503-506

 en Characterization of t cell clones from chagasic patients: predominance of cd8 surface phenotype in clones from patients with pathology
Washington R Cuna & Celeste Rodriguez Cuna

Abstract

Human Chagas' disease, caused by the protozoan Trypanosoma
cruzi, is associated with pathological processes whose
mechanisms are not known. To address this question, T cell
lines were developed from chronic chagasic patients peripheral
blood mononuclear cells (PBMC) and cloned. These T cell clones
(TCC) were analyzed phenotypically with monoclonal antibodies
by the use of a fluorescence microscope. The surface phenotype
of the TCC from the asymptomatic patient were predominantly
CD4 positive (86%). On the contrary, the surface phenotype CD8
was predominant in the TCC from the patients suffering from
cardiomegaly with right bundle branch block (83%), bradycardia
with megacolon (75%) and bradycardia (75%). Future studies
will be developed in order to identify the antigens eliciting
these T cell subpopulations.

Keywords
Trypanosoma cruzi - T cell clones - asymptomatic - pathology

 
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