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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 6, 1995, pp. 733-740
Bioline Code: oc95148
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 6, 1995, pp. 733-740

 en Chronic Experimental Infection by Trypanosoma cruzi in Cebus apella Monkeys
A Riarte; A Sinagra; M Lauricella; N Bolomo; M Moreno; P Cossio; R Arana & El Segura

Abstract

Twenty young male Cebus apella monkeys were infected with CA1
Trypanosoma  cruzi  strain and reinfected with CA1 or Tulahuen
T.cruzi strains, with different doses and parasite source. 
Subpatent parasitemia was usually demonstrated in acute and
chronic phases.  Patent parasitemia was evident in one monkey
in the acute phase and in four of them in the chronic phase
after re-inoculations with high doses of CA1 strain.
Serological conversion was observed in all monkeys; titers
were low, regardless of the methods used to investigate
anti-T. cruzi specific antibodies. Higher titers were induced
only when re-inoculations were performed with the virulent
Tulahun strain or high doses of CA1 strain.  Clinical,
electrocardiographic  and ajmaline test evaluations did not
reveal changes between  infected and control monkeys.
Histopathologically, cardiac lesions  were always 
characterized by focal or multifocal mononuclear infiltrates
and/or isolated fibrosis, as seen during the  acute and
chronic phases; neither amastigote nests nor active
inflammation and fibrogenic processes characteristic of human
acute and chronic myocarditis respectively, were observed. 
These morphological aspects  more closely resemble  those
found in the "indeterminate phase" and  contrast with the more
diffuse and progressive pattern of the human chagasic chronic
myocarditis. All monkeys survived and no mortality was
observed.

Keywords
Trypanosoma cruzi - chronic infection - reinfection - monkeys - Cebus apella - animal models

 
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