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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 1, 1996, pp. 63-70
Bioline Code: oc96010
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 1, 1996, pp. 63-70

 en Assessment of immunity induced in mice by glycoproteins derived from different strains and species of Leishmania
Guimaraes, Tania Mara Pinto Dabes; De Toledo, Vicente De Paulo Coelho Peixoto; Da Costa, Carlos Alberto; Da Costa, Roberto Teodoro; Genaro, Odair; Williams, Paul & Mayrink, Wilson

Abstract

A comparative study was undertaken on the immunogenic properties of 63kDa glycoproteins obtained from five different strains/species of Leishmania and assessed in C57BL/10 mice. The humoral immune response was assessed by ELISA  against the five different  antigens of the immunized animals.  The cellular immune response was derived from Leishmania. The response was found to be species-specific in all of determined by means of the cytokine profiles secreted by the spleen cells of immunized animals. The presence of g-IFN and IL-2, and the absence of IL-4 in the supernatants of cells stimulated by L. amazonensis antigen established that the cellular response is of Th1 type. The five glycoproteins tested were equally effective in protecting C57BL/10 mice against challenge by L. amazonensis. About 50% of the
immunized animals were protected for six months.

Keywords
Leishmania - glycoproteins - monoclonal antibodies

 
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