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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 1, 1996, pp. 111-116
Bioline Code: oc96019
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 1, 1996, pp. 111-116

 en N-terminal amino acid sequences of the major outer membrane proteins from a neisseria meningitidis group b strain isolated in brazil
De Simone, Salvatore Giovanni; Soares, Solange AF; Souza, Andre LA & Danelli, Maria GM

Abstract

The four dominant outer membrane proteins (46, 38, 33 and 28 kDa) were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in a semi-purified preparation of vesicle membranes of a Neisseria meningitidis (N44/89, B:4:P1.15:P5.5,7) strain isolated in Brazil. The N-terminal amino acid sequence for the 46 kDa and 28 kDa proteins matched that reported by others for class 1 and 5 proteins respectively, whereas the sequence (25 amino acids) for the 38 kDa (class 3) protein was similar to class 1 meningococcal proteins. The sequence for the 33 kDa (class 4) was unique and not homologous to any known protein.

Keywords
Neisseria meningitidis group B - outer membrane proteins - class specific proteins - N-terminal amino acid sequence

 
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