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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 2, 1996, pp. 211-216
Bioline Code: oc96042
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 2, 1996, pp. 211-216

 en Trypanosoma cruzi Infection in Offspring Born to Chagasic C^3H/He Mice
Silvana Marques de Araujo & Egler Chiari

Abstract

This study reports the effects of Trypanosoma cruzi
infection induced in C3H/He male and female mice born to
chagasic mice. An experimental model was established infecting
female C3H/He mice with a low virulent T. cruzi clone. In this
model, mating, fertilization, pregnancy evolution and delivery
was carried out successfully. The offspring was infected at
four, six and eigth weeks of age. The results showed that the
offspring born to chagasic mothers present decreased
resistance to acquired T. cruzi infection. This decreased
resistance was expressed by higher levels of parasitaemia and
higher mortality rates in offspring born to chagasic mothers
than in controls. Age and sex were shown to be important
factors of this phenomenon.

Keywords
maternal influence decreased resistance maternal- fetal relationship Trypanosoma cruzi

 
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