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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 3, 1996, pp. 359-362
Bioline Code: oc96071
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 3, 1996, pp. 359-362

 en Laboratory Indicators for Monitoring HIV Disease
Raul Scott Pereira & Matthew Reginald Helbert

Abstract

Immunological monitoring of disease progression following
HIV infection and seroconversion illness, latency and AIDS, not
only helps in the basic investigation of the natural history of
the viral  infection in man, but also can assist in prognosis and
treatment of AIDS-defining illnesses. However, outside clinical
trials, these tests should be selected and used  in clinical
practice only if they are validated as relevant and effective.
The absolute CD4+ T-helper lymphocyte count, measured by flow
cytometry,  has emerged as the best available investigation, but
needs care in sampling due to diurnal and circadian rhythms,
effects of age, pregnancy, therapy, intercurrent infections and
technique. Sampling should provide a baseline and trends -
monthly intervals initially, then quarterly in uncomplicated
cases.

Keywords
T helper - AIDS - neopterin - b2microglobulin - audit

 
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