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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 3, 1996, pp. 389-394
Bioline Code: oc96077
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 3, 1996, pp. 389-394

 en Phenotypes of Lung Mononuclear Phagocytes in HIV Seronegative Tuberculosis Patients: Evidence for New Recruitment and Cell Activation
Jose R Lapa e Silva; Cristiane Linhares; Neio Boechat; Lorena Rego; Maria da Gloria Bonecini Almeida; Afranio L Kritski & John L Ho

Abstract

Mycobacterium tuberculosis preferentially resides in
mononuclear phagocytes. The mechanisms by which mononuclear
phagocytes keep M. tuberculosis in check or by which the
microbe evades control to cause disease remain poorly understood.
As an initial effort to delineate these mechanisms, we examined
by immunostaining the phenotype of mononuclear phagocytes
obtained from lungs of patients with active tuberculosis. From
August 1994 to March 1995, consecutive patients who had an
abnormal chest X-ray, no demostrable acid-fast bacilli in sputum
specimens and required a diagnostic bronchoalveolar lavage (BAL)
were enrolled. Of the 39 patients enrolled, 21 had
microbiologically diagnosed tuberculosis. Thirteen of the 21
tuberculosis patients were either HIV seronegative (n = 12) or
had no risk factor for HIV and constituted the tuberculosis
group. For comparison, M. tuberculosis negative patients
who had BAL samples taken during this time (n = 9) or normal
healthy volunteers (n = 3) served as control group.

Keywords
pulmonary tuberculosis - alveolar macrophages - activation - monoclonal antibodies

 
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