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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 4, 1996, pp. 491-498
Bioline Code: oc96094
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 4, 1996, pp. 491-498

 en Involvement of Regional Lymph Nodes after Penetration of Schistosoma mansoni Cercariae in Naive and Infected Mice
Silene P Lozzi; Conceic o RS Machado; Silvia E Gerken & Tomas A Mota-Santos

Abstract

The parotid lymph nodes of naive and previously infected
Balb/c mice were studied after, respectively, infection and
re-infection with cercariae of Schistosoma mansoni via
the ears. Schistosomula were able to pass through the lymph
node by following the lymph flow or by penetrating the veins
of the medullary cords. The number of nodal mast cells was
higher from day 2 to 6 of primary infection; and from day 5 to
11 of re-infection. The amount of degranulating mast cells was
significantly higher at day 4 of infection and at day 1 of re-
infection. Eosinophils characterized the nodal inflammatory
processes observed after day 5 in both primarily-infected and
re-infected mice. However, only in the latter the eosinophils
were able to adhere to the larval surface. In primarily-
infected mice, no intranodal larva presented signs of
degeneration. In contrast, in re-infected animals, some
degenerating larvae were found inside eosinophilic
infiltrates. The eosinophils reached the nodal tissue by
migrating through the high endothelial venules and their
collecting veins.

Keywords
Schistosoma mansoni - lymph nodes - schistosomulum migration - eosinophils - mast cells - high endothelial venules

 
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