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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 5, 1996, pp. 601-607
Bioline Code: oc96109
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 5, 1996, pp. 601-607

 en Defective Production of Interleukin 2 in Patients with Chagas' Disease. Purified IL-2 Augments in Vitro Response in Patients with Chagasic Cardiomyopathy
Luis Briceno & Walter Mosca

Abstract

The production of interleukin 2 (IL-2) by peripheral blood
mononuclear cells, from patients with different clinical forms
of Chagas  disease and healthy controls, was evaluated after
stimulation with Trypanosoma cruzi antigen, PPD and
PHA. PHA induced higher production of IL-2 in infected
patients than healthy controls. No diferences were found
between infected groups. With PPD the trend was similar, the
only difference was that asymptomatic infected patients (INF)
showed higher levels of IL-2 production than patients with
cardiomyopathy (CDM). With T. cruzi antigen, most
patients showed little or no IL-2 production at 24 hr, a peak
at 48 hr and an abrupt fall at 72 hr. A similar pattern of IL-
2 production was observed in INF and CDM. To evaluate the
physiologic relevance of the deficit in IL-2 production, we
studied the effect of non-mitogenic concentratios of IL-2 in
the proliferative response to specific antigens. The addition
of IL-2 only enhanced the proliferative response of CDM
patients. These observations suggest that patients suffering
Chagas' disease, particularly CDM, have a significant
reduction in the capacity to produce IL-2. These findings 
could be of importance in the pathogenesis of Chagas' disease.

Keywords
Trypanosoma cruzi - Chagas' disease - immunoparasitology - interleukin-2

 
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