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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 5, 1996, pp. 627-635
Bioline Code: oc96113
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 5, 1996, pp. 627-635

 en Antileishmanial Action of Organometallic Complexes of Pt(II) and Rh(I)
CM Mesa-Valle; V Moraleda-Lindez; D Craciunescu & A Osuna

Abstract

The three organometallic complexes [(Cis-Pt^II (DDH) (2,5-
Dihidroxibenzensulfonic)^2, Rh^I (CO)2 Cl(2-
Aminobenzothiazole) and Rh^I (CO)2 Cl(5-Cl-2-
Methilbenzothiazole)]  used in this study had been previously
found to have a high in vitro activity against
promastigote and amastigote like forms of Leishmania
donovani. Here, the cytotoxic effect of these new
organometallic complexes on the J-774 macrophages were
studied. Only the Rh^I(CO)2 Cl (2-Aminobenzothiazole) complex
induced substantial toxicity in the cells.

Also, we assayed the effect of this complex on the parasite s biosynthesis of macromolecules. The Rh^I(CO)2Cl (5-Cl-2- Methylbenzothiazole) complex inhibited DNA, RNA, and protein synthesis. On the other hand, the two other compounds tested did not inhibit the incorporation of radioactive precursors. Finally important ultrastructural alterations in the parasites treated with the two non-cytotoxic complexes were observed.

Keywords
Organometallic complexes - Leishmania donovani - in vitro toxicity - mechanism of action

 
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