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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 6, 1996
Bioline Code: oc96137
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 6, 1996

 en The Serological Differentiation of Acute and Chronic Schistosomiasis Japonica Using IgA Antibody to Egg Antigen
Cen Liping; Lg Viana; Tc Melo Garcia; Alt Rabello & N Katz

Abstract

Two groups of Schistosoma japonicum infected
patients (acute and chronic ) and non-infected individuals
were studied using IgA antibody  to  egg antigen (SEA) and IgG
and IgM antibodies to keyhole  limpet  haemocyanin (KLH). The
means and standard deviation of the optical density in ELISA
of acute, chronic and negative groups for IgA anti-SEA were
583+/-124.7, 98.2+/-78.8 and 82.2+/-39. 3,  respectively.
There  was a statistically significance between acute patients
and chronic patients (P{0.01).  The means and standard
deviation of IgG and IgM antibodies to KLH were 501.5+/-150.6,
113.0+/-79.1, 28.8+/-56.3 and 413.6+/-148.5, 70.2+/-14.8,
65.3+/-45.3, respectively. The  detection  results  of IgA  to 
SEA  compared with the IgG and IgM to KLH did not demonstrate
a significant difference (P}0.01). The sensitivities of IgA to
SEA  and IgG  and  IgM antibodies to KLH for the detection of
acute infection were 95.24%,  90.48% and 85.71%, respectively.
Therefore, this  study  showed that  the detection of IgA to
SEA is also a useful new method for the serological
differentiation  of  acute  and  chronic  schistosomiasis
japonica  in humans.

Keywords
acute and chronic schistosomiasis japonica - serological differentiation

 
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