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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 1, 1997, pp. 15-20
Bioline Code: oc97003
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 1, 1997, pp. 15-20

 en Asymptomatic Leishmania chagasi infection in relatives and neighbors of patients with visceral Leishmaniasis
Argemiro D'Oliveira Junior; Sergio Ricardo M Costa; Aurinha Bispo Barbosa; Maria de la Gloria Orge Orge & Edgar M Carvalho

Abstract

The frequency of asymptomatic infection among relatives and neighbors of
cases of visceral leishmaniasis (VL) was compared and characterization of
the immunological response in these subjects was performed. Cases were
from a new endemic area, close to the beach and near Salvador, capital of
the State of Bahia, Brazil. The characterization of asymptomatic infection
was made using a skin reaction test and detection of antibody to 
Leishmania chagasi by the ELISA test. To characterize the immunological
response of these subjects with asymptomatic L. chagasi infection the
cytokines profile and the lymphoproliferative response were determined
after stimulation of lymphocytes by L. chagasi antigen. There was no
difference in the frequency of L. chagasi infection in relatives (45%) and
in neighbors (27%) of cases of VL (P}0.05). The immunological response from
these subjects was characterized by high production of IFN-gamma and a low
production of IL-10 and a good lymphoproliferative response to L. chagasi
antigen.

Keywords
visceral leishmaniasis - asymptomatic infection - relatives' infections

 
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