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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 2, 1997, pp. 245-250
Bioline Code: oc97048
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 2, 1997, pp. 245-250

 en Tuberculin skin test and CD4+/CD8+ T cell counts in adults infected with the Human Immunodeficiency Virus in Medellin, Colombia
JI Rodriuez; M Arias; SC Paris; MP Arbelaez; J Betancur & LF Garcia

Abstract

To evaluate the effect of BCG vaccination and T lymphocyte subpopulations
on the reactivity to the tuberculin skin test, 113 asymtomatic HIV+
individuals were tuberculin tested by intradermal injection of 5TU of
purified protein derivative and the levels of circulating lymphocyte (CD3,
CD4 and CD8) subpopulations determined by indirect immunofluorescence.
Ninety-two percent of the subjects included in the study were males. The
mean age of the group was 32.1+/-7.4 years. Sixty-two percent presented a
BCG scar. However, only 22% exhibited positive tuberculin reactions (}5mm)
irrespective of the presence of the BCG scar. Tuberculin positive
individuals exhibited higher CD4+ cell counts (p=0.004) and CD4+/CD8+
ratios (p=0.006) than tuberculin negative ({5mm) HIV+ individuals. The
number of individuals with positive tuberculin reactions was significantly
higher in subjects with more than 500 CD4+ lymphocytes/ml (p=0.02) or
CD4+/CD8+ ratios }1.12 (p=0.002). 

These results suggest that a prior BCG vaccination does not influence the reactivity to the tuberculin skin test in HIV+ asymptomatic individuals and that the number of CD4+ lymphocytes and the CD4+/CD8+ ratio positively correlate with the tuberculin reactivity.

Keywords
HIV - tuberculin - BCG vaccination - CD4 - CD8

 
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