Goyazensolide, a component extracted of Eremanthus goyazensis showed a
significant inhibitory effect on egg-laying of Schistosoma mansoni during
in vitro cultivation of this parasite. Motility of the worms was also
reduced under treatment with goyazensolide and 90% of mortality was reached
with concentrations up to 4ug/ml. It has found that separated worms were
more susceptible than worms pairing during drug exposition and female alone
was significantly more susceptible than male worm in the same conditions of
in vitro cultivation.
Natural products isolated from plants represent potential sources for the
identification of structures useful for the design of alternative molecules
to be used as new drug substances against several infectious diseases.