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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 3, 1997, pp. 427-429
Bioline Code: oc97078
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 3, 1997, pp. 427-429

 en Effects of goyazensolide during in vitro cultivation of Schistosoma mansoni
Leo Roberto Barth; Ana Paula Moraes Fernandes; Joao Tadeu Ribeiro-Paes & Vanderlei Rodrigues

Abstract

Goyazensolide, a component extracted of Eremanthus goyazensis showed a
significant inhibitory effect on egg-laying of Schistosoma mansoni during
in vitro cultivation of this parasite. Motility of the worms was also
reduced under treatment with goyazensolide and 90% of mortality was reached
with concentrations up to 4ug/ml. It has found that separated worms were
more susceptible than worms pairing during drug exposition and female alone
was significantly more susceptible than male worm in the same conditions of
in vitro cultivation. 

Natural products isolated from plants represent potential sources for the identification of structures useful for the design of alternative molecules to be used as new drug substances against several infectious diseases.

Keywords
Schistosoma mansoni - schistosomiasis - sesquiterpene lactones - in vitro cultivation

 
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