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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 4, 1997, pp. 503-507
Bioline Code: oc97090
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 4, 1997, pp. 503-507

 en Immune response to Trypanosoma cruzi shed acute phase antigen in children from an endemic area for Chagas' disease in Bolivia
Simone Frederique Breniere; Nina Yaksic; Jenny Telleria; Marie-France Bosseno; Francois Noireau; Patrick Wincker & Daniel Sanchez

Abstract

A field study of the immune response to the shed acute phase antigen (SAPA)
of Trypanosoma cruzi was carried out in the locality of Mizque, Cochabamba
department, Bolivia. Schoolchildren (266), with an average of 8.6+/-3.6
years, were surveyed for parasitological and serological diagnosis, as well
as antibodies directed against SAPA using the corresponding recombinant
protein in ELISA. The antibodies against SAPA were shown in 82% of patients
presenting positive serological diagnosis (IgG specific antibodies). The
positive and negative predictive values were 0.88. Antibodies anti-SAPA
were shown in 80.8% of the chagasic patients in the initial stage of the
infection (positive IgM serology and/or positive buffy coat (BC) test) and
in 81.4% of the patients in the indeterminate stage of the infection
(positive IgG serology with negative BC and IgM tests). These results show
that the anti-SAPA response is not only present during the initial stage of
the infection (few months) but extends some years after infection.

Keywords
Trypanosoma cruzi - shed acute-phase antigen - humoral response - serological diagnosis

 
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