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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 5, 1997, pp. 589-593
Bioline Code: oc97110
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 5, 1997, pp. 589-593

 en Toxoplasma gondii antigenuria in patients with acquired immune deficiency syndrome
Alberto Fachado; Lisset Fonseca; Luis Fonte; Esteban Alberti; Raymundo Cox & Frank Bandera

Abstract

A longitudinal study was performed with sera and urine of patients with
acquired immune deficiency syndrome (AIDS), taken before, during and after
clinically Toxoplasma infection. The tested patients were followed for an
average of two years. The titres of the specific IgG and IgM antibodies
were measured by an indirect fluorescent antibody test (IFAT), and the
appearance of circulating antigens of T. gondii was determined in 36 urine
samples of 13 patients with neurotoxoplasmosis by means of the
coagglutination test.  

The presence of T. gondii antigens in the urine of AIDS patients by this test was correlated with the immunoblot technique, with clinical symptoms and also with pathological findings.

Our results indicate that the detection of T. gondii antigens in the urine of AIDS patients can be regarded as a rapid and efficient method for the diagnosis of acute toxoplasmosis.

Keywords
Toxoplasma gondii antigens - coagglutination test - AIDS patients - neurotoxoplasmosis

 
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