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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 5, 1997, pp. 663-667
Bioline Code: oc97125
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 5, 1997, pp. 663-667

 en Evidentiation of Paramyosin (Sm-97) as a modulating antigen on granulomatous hypersensitivity to Schistosoma mansoni eggs
Cristine Hirsch; Claudia Carvalho-Queiroz; Gloria R Franco; Sergio DJ Pena; Andrew JG Simpson & Alfredo M Goes

Abstract

A Schistosoma mansoni adult worm anionic fraction (PIII) has previously
been shown to protect mice against challenge infection and to reduce
pulmonary and hepatic granulomatous hypersensitivity. Serum from
PIII-immunized rabbit was used to screen a lambda gt11 cDNA library from S.
mansoni adult worm in order to identify antigens capable of modulating
granulomatous hypersensitivity. We obtained four clones with 400
(Sm-III.11), 900 (Sm-III.16), 1100 (Sm-III.10) and 1300 (Sm-III.12) bp of
length. All clone-specific antibodies were able to recognize most of the
PIII components. The sequence analysis showed that these clones presented
high homology with S. mansoni paramyosin (Sm-97). These findings ascribe a
new function to this antigen with an important role in modulation of
granulomatous hypersensitivity to S. mansoni eggs.

Keywords
Paramyosin - modulation - granuloma - Schistosoma mansoni

 
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