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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 5, 1997, pp. 693-697
Bioline Code: oc97130
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 5, 1997, pp. 693-697

 en Impact of antifibrotic treatment on the course of Schistosoma mansoni infection in murine model
Michal Giboda & James M Smith

Abstract

Administration of an antifibrotic agent as an adjunct to antihelmintic
treatment with the objective of morbidity reduction was investigated in the
murine schistosomiasis mansoni model. Antifibrotic, beta-aminopropionitrile
treatment has a profound effect on the cellular matrix composition of the
liver granuloma of Schistosoma mansoni infected mice when given alone,
resulting in increase macrophage infiltration. These macrophages, in
response to stimulation with soluble egg antigen or lipopolysaccharide
produced elevated levels of nitric oxide but low levels of tumor necrosis
factor alpha compared to untreated infected mice. This also correlated with
reduced liver granuloma size. In spite of low numbers of eggs in the liver,
mice receiving a combine treatment had a high level of resistance to a
challenge infection compared with mice receiving only praziquantel. Those
mice also exhibited a reduced lymphocyte proliferative response, similar to
that of infected untreated mice. Antifibrotic treatment has an impact on
the dynamic of the cellular nature of granulomas and impacts on the host
immunity to infection.

Keywords
Schistosoma mansoni - beta-aminopropionitrile - antifibrotic treatment - granulomas cells - cytokines - lymphocytes proliferation - resistance

 
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