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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. 6, 1997, pp. 835-841
Bioline Code: oc97156
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. 6, 1997, pp. 835-841

 en Compositional constraints in the extremely GC-poor genome of Plasmodium falciparum
Hector Musto; Simone Caccio; Helena Rodriguez-Maseda & Giorgio Bernardi

Abstract

We have analyzed the compositional properties of coding (protein encoding)
and non-coding sequences of Plasmodium falciparum, a unicellular parasite
characterized by an extremely AT-rich genome. GC% levels, base and
dinucleotide frequencies were studied. We found that among the various
factors that contribute to the properties of the sequences analyzed, the
most relevant are the compositional constraints which operate on the whole
genome.

Keywords
Plasmodium falciparum - GC levels - dinucleotides - genome organization

 
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