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From Allergy To Schistosomes: Role Of Fc Receptors And Adhesion Molecules In Eosinophil Effector Function
Nutten, Sophie; Trottein, Francois; Gounni, Abdelillah Soussi; Papin, Jean-Paul; Capron, Andre & Capron, Monique
Abstract
The dual function of eosinophils has been evidenced in protective
immunity against parasites as well as in pathological manifestations during
allergic disorders. We have demonstrated that a new class of IgE receptors,
FceRII/CD23, was involved in the functional duality of eosinophils and
other proinflammatory cells. More recently, we have shown that FceRI, the
high affinity IgE receptor thought to be only expressed by basophils and
mast cells, was involved in eosinophil-mediated cytotoxicity against
schistosomes as well as in mediator release. These results favour the view
that both IgE and its receptors have been primarily associated to a
protective immune response, rather than to pathology. Not only IgE
receptors but also members belonging to the family of adhesion molecules
can participate as co-receptors in eosinophil effector function. The
inhibitory role of monoclonal antibodies to LewisX (LeX, CD15) or to
selectins in eosinophil-mediated cytotoxicity towards schistosomes and the
detection of LeX and 'selectin-like' molecules on schistosomula surface
indicate a double interaction mediated by selectins and their carbohydrate
ligands between eosinophils and schistosomula. These results suggest new
functions for these adhesion molecules, previously known to be involved
mainly in cell infiltration.
Keywords
eosinophils - schistosomes - allergy - Fc receptors - adhesion molecules
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