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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 33-35
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Bioline Code: oc97166
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 33-35
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Bone Marrow Contribution To Eosinophilic Inflammation
Denburg, Judah A.; Wood, Lorna; Gauvreau,Gail; Sehmi, Roma; Inman, Mark D. & O'Byrne, Paul M.
Abstract
Allergen-induced bone marrow responses are observable in human allergic
asthmatics, involving specific increases in eosinophil-basophil progenitors
(Eo/B-CFU), measured either by hemopoietic assays or by flow cytometric
analyses of CD34-positive, IL-3Ra-positive, and/or IL-5-responsive cell
populations. The results are consistent with the upregulation of an
IL-5-sensitive population of progenitors in allergen-induced late phase
asthmatic responses. Studies in vitro on the phenotype of developing
eosinophils and basophils suggest that the early acquisition of IL-5Ra, as
well as the capacity to produce cytokines such as GM-CSF and IL-5, are
features of the differentiation process. These observations are consistent
with findings in animal models, indicating that allergen-induced increases
in bone marrow progenitor formation depend on hemopoietic factor(s)
released post-allergen. The possibility that there is constitutive marrow
upregulation of eosinophilopoiesis in allergic airways disease is also an
area for future investigation.
Keywords
hemopoiesis - asthma - inflammation - IL-5 - eosinophils - basophils
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