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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 115-123
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Bioline Code: oc97176
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 115-123
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Signal Transduction And Activation Of The NADPH Oxidase In Eosinophils
Lindsay, Mark A. & Giembycz, Mark A.
Abstract
Activation of the eosinophil NADPH oxidase and the subsequent release of
toxic oxygen radicals has been implicated in the mechanism of parasite
killing and inflammation. At present, little is known of the signal
transduction pathway that govern agonist-induced activation of the
respiratory burst and is the subject of this review. In particular, we
focus on the ability of leukotrine B4 to activate the NADPH oxidase in
guinea-pig peritoneal eosinophils which can be obtained in sufficient
number and purity for detailed biochemical experiments to be performed.
Keywords
leukotriene B4 - eosinophil - NADPH oxidase - signal transduction
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© Copyright 1997 Fundacao Oswaldo Cruz - Fiocruz
Alternative site location: http://memorias.ioc.fiocruz.br
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