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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 193-196
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Bioline Code: oc97185
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 193-196
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A Comparison Of The Inhibitory Activity Of Selective PDE4 Inhibitors On Eosinophil Recruitment In Guinea Pig Skin
Teixeira, Mauro M.; Miotla, J.M.; Cooper, N.; Gristwood, R.W. & Hellewell, P.G.
Abstract
The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4
inhibitors in eosinophils is associated with inhibition of the activation
and recruitment of these cells. We have previously shown that systemic
treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil
migration in guinea pig skin. In the present study we compare the oral
potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840
on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401
were equally effective and potent when given by the oral route and much
more active than the PDE4 inhibitor CDP 840. We suggest that this guinea
pig model of allergic and mediator-induced eosinophil recruitment is both a
sensitive and simple tool to test the efficacy and potency of PDE4
inhibitors in vivo.
Keywords
eosinophils - phosphodiesterase inhibitors - rolipram - allergic inflammation
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