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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 93, No. 2, 1998, pp. 243-246
Bioline Code: oc98046
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 93, No. 2, 1998, pp. 243-246

 en RESEARCH NOTE - Structure of the knob protein gene of the Saimiri monkey-adapted Palo Alto strain of Plasmodium falciparum
Wanda Chalvet; Jean-Francois Pouliquen & Thierry Fandeur

Abstract

The histidine-rich protein is the major component of the knob-like
protrusions detected on the membrane of both human and monkey erythrocytes
infected with Plasmodium falciparum (SA Luse & LH Miller 1971, M
Hommel et al. 1982, F Ardeshir et al. 1987. The knobs on the red blood cell
surface are generally associated with strain pathogenicity and virulence.
Isolates collected from naturally infected patients are consistently of
knobby phenotype (Hommel et al.) and knobless lines were reported to be
less virulent in monkey models (S Langreth & E Peterson 1985, T Fandeur et
al. 1992).

Keywords
Plasmodium falciparum - histidine-rich protein - Palo Alto parasites - squirrel monkey - strain infectivity

 
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