Much has been learned about how HIV-induced immune dysfunction contributes
to B cell hyperactivation, and potentially, to the pathogenesis of
AIDS-lymphoma. However, further studies are needed to fully understand how
HIV infection and immune dysfunction promote B cell hyperactivation and the
development/growth of AIDS-lymphoma. In particular, studies are needed to
define the role of HHV8 vIL6, IL6 receptor-expression, and lymphocyte
surface stimulatory molecules, in promoting B cell hyperactivation or
lymphoma cell growth.