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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 93, No. 3, 1998, pp. 373-381
Bioline Code: oc98072
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 93, No. 3, 1998, pp. 373-381

 en Immune dysfunction and the pathogenesis of AIDS-associated non-Hodgkin's lymphoma
Otoniel Martinez-Maza; Daniel Widney; Meta van der Meijden; Reba Knox; Angela Echeverri; Elizabeth C Breen; Larry Magpantay & Steven A Miles

Abstract

Much has been learned about how HIV-induced immune dysfunction contributes
to B cell hyperactivation, and potentially, to the pathogenesis of
AIDS-lymphoma. However, further studies are needed to fully understand how
HIV infection and immune dysfunction promote B cell hyperactivation and the
development/growth of AIDS-lymphoma. In particular, studies are needed to
define the role of HHV8 vIL6, IL6 receptor-expression, and lymphocyte
surface stimulatory molecules, in promoting B cell hyperactivation or
lymphoma cell growth.

Keywords
B lymphocytes - HIV - AIDS - lymphoma - interleukin 6 - HHV8

 
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