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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 93, No. 4, 1998, pp. 439-440
Bioline Code: oc98086
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 93, No. 4, 1998, pp. 439-440

 en RESEARCH NOTE - Detection of type 16 Human Papillomavirus DNA in formalin-fixed invasive squamous cells from laryngeal cancers by polymerase chain reaction
Yudira Soto; Odalys Valdes; Mayra Mune; Tamara Pimentel & Rosa Ramirez

Abstract

To date approximately 77 distinct human papillomavirus (HPV) genotypes have
been described and the genomic sequences of most of them have been fully
analyzed. About 30 additional partial sequences have been obtained from
putative novel HPV types, suggesting that the total number of existing HPV
genotypes is in excess of 100. HPV cause benign tumors in the respiratory
tract. Mounting evidence suggests that they also play a role in the
etiology of a subset of head and neck cancers. Carcinomas in patients with
a history of recurrent respiratory papillomatosis are caused clearly by
persistent HPV interacting with one or more carcinogenic agents. 
Previous studies have suggested squamous neoplasia of the larynx and may
also be HPV related.

Keywords
human papillomavirus - laryngeal cancer - polymerase chain reaction - Cuba

 
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