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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 93, No. 5, 1998, pp. 625-626
Bioline Code: oc98119
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 93, No. 5, 1998, pp. 625-626

 en RESEARCH NOTE - Molecular Epidemiology of Den-2 Virus In Brazil
MP Miagostovich; RMR Nogueira; HG Schatzmayr & RS Lanciotti

Abstract

Dengue (DEN) viruses belong to the family
Flaviviridae, genus Flavivirus, and occur as four
antigenically related, but distinct serotypes designated DEN-1,
2, 3 and 4 (EG Westaway et al. 1985 Intervirology 24:
183-192). The viruses are characterized by a single strand of RNA
associated with a core protein, in a nucleocapside surrounded by
a lipid envelope. The genoma consist of a single open reading
frame coding for core protein (C), precursor of the membrane
protein (prM) and envelope (E) structural proteins, followed by
the non structural proteins NS1, NS2a, NS2b, NS3, NS4a, NS4b and
NS5 (FZ Heinz & JT Roehring 1990 p. 289-305. In MHV Van
Regenmorte, AR Neurath (eds), Immunochemistry of Viruses, II.
The Basis for Serodiagnosis and Vaccines, Elsevier).

Keywords
dengue virus type 2 - sequencing - Brazil

 
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