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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 93, No. 5, 1998, pp. 677-683
Bioline Code: oc98128
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 93, No. 5, 1998, pp. 677-683

 en Genetic Data Showing Evolutionary Links between Leishmania and Endotrypanum
Elisa Cupolillo; Luiza OR Pereira; Octávio Fernandes; Marcos P Catanho; Júlio C Pereira; Enrique Medina-Acosta & Gabriel Grimaldi Jr


Striking similarities at the morphological, molecular and
biological levels exist between many trypanosomatids isolated
from sylvatic insects and/or vertebrate reservoir hosts that make
the identification of medically important parasites demanding.
Some molecular data have pointed to the relationship between some
Leishmania species and Endotrypanum, which has an
important epidemiological significance and can be helpful to
understand the evolution of those parasites. In this study, we
have demonstrated a close genetic relationship between
Endotrypanum and two new leishmanial species, L. (V.)
colombiensis and L. (V.) equatorensis. We have used (a)
numerical zymotaxonomy and (b) the variability of the internal
transcribed spacers of the rRNA genes to examine relationships in
this group. The evolutionary trees obtained revealed high genetic
similarity between L. (V.) colombiensis, L. (V.)
equatorensis and Endotrypanum, forming a tight cluster
of parasites. Based on further results of (c) minicircle kDNA
heterogeneity analysis and (d) measurement of the sialidase
activity these parasites were also grouped together.

Leishmania colombiensis - Leishmania equatorensis - Endotrypanum - multilocus enzyme electrophoresis - molecular characterization - numerical analysis - sialidase activity - kDNA

© Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
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