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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 94, No. 1, 1999, pp. 67-70
Bioline Code: oc99014
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 94, No. 1, 1999, pp. 67-70

 en RESEARCH NOTE - Vaccination of C57BL/10 Mice against Cutaneous Leishmaniasis. Use of Purified gp63 Encapsulated into Niosomes Surfactants Vesicles: A Novel Approach
CM LezamaDávila

Abstract

Leishmaniasis comprises a group of diseases caused by different species of parasites of the genus Leishmania. It is widely accepted that cell mediated immune response plays a major role in the development of this disease, and most experimental evidence indicates that CD4+ T cells are the primary, but not the only population of cells involved in the evolution of this infection in the mouse and, perhaps, in the human being as well. There is currently no commercial vaccines aimed to prevent L. m. mexicana infections in humans. Although, experimental murine infection induced with Leishmania could be prevented by previous inoculation of attenuated parasites or purified molecules.

Keywords
vaccination - Leishmania m. mexicana - niosomes

 
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