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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 94, No. 1, 1999, pp. 71-76
Bioline Code: oc99015
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 94, No. 1, 1999, pp. 71-76

 en Resolution of an Infection with Leishmania braziliensis Confers Complete Protection to a Subsequent Challenge with Leishmania major in BALB/c Mice
Hermenio C Lima; Gregory K DeKrey & Richard G Titus

Abstract

Both Leishmania major and L. braziliensis induce cutaneous
leishmaniasis in BALB/c mice. Whereas BALB/c mice die of infection with L. major,
they cure an infection with L. braziliensis. We report here that after curing an infection
with L. braziliensis, BALB/c mice are resistant to challenge with L. major.
When challenged with L. major, L. braziliensis pre-treated BALB/c mice mounted a
delayed-type hypersensitivity response to L. major and produced high amounts of
interferon -γ (IFN-γ) but low amounts of interleukin-4. The IFN-γ produced
by the L. braziliensis pre-infected mice was involved in the protection seen against
L. major challenge since treating the mice with a neutralizing anti-IFN-γ abrogated the protection. This suggests that cross-reactive antigen epitopes exist between L. braziliensis and L. major and that
pre-infection with L. braziliensis primes BALB/c mice to epitopes on L. major
that can elicit a protective Th1 response to the parasite.

Keywords
Leishmania braziliensis - Leishmania major - mice - cross-protection - cytokines

 
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