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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 94, No. 4, 1999, pp. 433-440
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Bioline Code: oc99081
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 94, No. 4, 1999, pp. 433-440
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The Epidemiological Impact of Antimeningococcal B Vaccination in Cuba
Antonio Pérez Rodríguez; Félix Dickinson; Alberto Baly & Ramón Martinez
Abstract
The incidence of invasive meningococcal disease (IMD) before (1984-1988) and after (1989-1994), a nationwide intervention with VA-MENGOC-BC vaccination started in 1989, was compared. The prevaccination period incidence density (ID> 8.8/ 105year-person) was higher than the postvaccination ID (ID< 6.5/ 105 year-person). The percentage proportional differences from the start to the end of each period of ID in the vaccinal period was higher (87%) than the prevaccinal (37%) with
significant differences among vaccinated groups (< 25 years old). A break-point (Chow test) was confirmed by the decrease in the ID between 1989 and 1990 in children under 1 year old, 5-9,
10-14, 15-19 and 50-54 years. Comparison of ID using maps showed a decrease in IMD in all municipalities during the postvaccination period. These findings support the epidemiological impact of VA-MENGOC-BC vaccination in the reduction of IMD morbidity.
Keywords
invasive meningococcal disease - impact of vaccination - antimeningococcal B vaccine - vaccine effectiveness - control of epidemic - Cuba
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© Copyright 1999 Fundacao Oswaldo Cruz - Fiocruz Alternative site location: http://memorias.ioc.fiocruz.br
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