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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 94, No. 5, 1999, pp. 675-678
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Bioline Code: oc99126
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 94, No. 5, 1999, pp. 675-678
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Antibacterial Activity of Ocimum gratissimum L. Essential Oil
Celso Vataru Nakamura; Tania Ueda-Nakamura; Erika Bando; Abrahão Fernandes Negrão Melo; Díogenes Aparício Garcia Cortez & Benedito Prado Dias Filho
Abstract
The essential oil (EO) of Ocimum gratissimum inhibited
Staphylococcus aureus at a concentration of 0.75 mg/ml. The minimal inhibitory
concentrations (MICs) for Shigella flexineri, Salmonella enteritidis, Escherichia coli,
Klebsiella sp., and Proteus mirabilis were at concentrations ranging from 3 to 12
μg/ml. The endpoint was not reached for Pseudomonas aeruginosa (>=24 mg/ml). The MICs of the reference drugs used in this study were similar to those presented in other reports. The
minimum bactericidal concentration of EO was within a twofold dilution of the MIC for this
organism. The compound that showed antibacterial activity in the EO of O.
gratissimum was identified as eugenol and structural findings were further supported by
gas chromatography/mass spectra retention time data. The structure was supported by
spectroscopic methods.
Keywords
Ocimum gratissimum - essential oil - eugenol - antimicrobial activity
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